PUREMIX SPIRULINA

“...diets supplemented with Spirulina significantly enhanced immune response and gut health in dogs.” – Satyaraj E, Reynolds A, Engler R, Labuda J, Sun P. Supplementation of Diets With Spirulina Influences Immune and Gut Function in Dogs. Front Nutr. 2021 May 28;8:667072. Zhang HQ, Lin AP, Sun Y, Deng YM. Chemo - and radio-protective effects of polysaccharide of Spirulina platensis on hemopoietic system of mice and dogs. Acta Pharmacol Sin. 2001 Dec;22(12):1121-4.​

Improved vitality - by helping balance and stabilize the immune system, it frees up more metabolic energy for vitality. Spirulina possesses antibacterial properties, including activity against Staphylococcus aureus MTCC 96, Salmonella typhimurium MTCC 98, Escherichia coli MTCC 443, Pseudomo-16 K. Kazimierska, J. Kępińska-Pacelik, W. Biel nas aeruginosa MTCC 424, and Proteus vulgaris MTCC 426 (Bhowmik et al. 2009; Kumar et al. 2011).

• Spirulina supplementation reduces the levels of aminotransferase and alkaline phosphatase in the blood, which is also linked to its anti-inflammatory properties (Rasool et al. 2006).
• T K Mao, J Van de Water, M E Gershwin, Effects of a Spirulina-based dietary supplement on cytokine production from allergic rhinitis patients, 2005

• It has been demonstrated that Spirulina promotes the growth of lactic acid bacteria, which are classified as probiotic organisms and help maintain a balance between harmful and beneficial microorganisms in the gastrointestinal tract, thereby improving intestinal absorption (Bhowmik et al. 2009).
• The positive impact of Spirulina supplementation in the diet of dogs on gut microbiota can be observed after just one month of use (Delsante et al. 2022). Supplementing dogs’ diets with Spirulina at a concentration of 0.2% has a prebiotic effect on the stability of gut flora in dogs, resulting in an improved immune response (Satyaraj et al. 2021). It has also been demonstrated in laboratory animals that Spirulina supplementation at a concentration of 3% in a high-fat diet for three months inhibits chronic inflammation, gut dysbiosis, and modulates intestinal permeability (Yu et al. 2020).
• Spirulina also exhibits prebiotic properties and modulates the microflora of the gastrointestinal tract (Patel et al. 2021)
• Yu T, Wang Y, Chen X, Xiong W, Tang Y, Lin L. Spirulina platensis alleviates chronic inflammation with modulation of gut microbiota and intestinal permeability. J Cell Mol Med. 2020 Aug;24(15):8603-8613.

• Products containing Spirulina are also used as supportive treatment for skin problems. GLA contributes to the reconstruction and protection of the skin’s barrier layer, protects the skin from infections, and alleviates inflammation. Additionally, it soothes irritations, redness, and counteracts dryness and scaling of the skin. Clinical studies in atopic dogs have shown positive effects of diet enrichment with a combination of EPA, DHA, and GLA (Abba et al. 2005). Significant improvement was observed in animals with early signs of atopy compared to those with chronic atopy. In dogs with atopic dermatitis, disturbances in the structure of extracellular lipid lamellae have been found, as they are thinner and not continuously arranged (Piekutowska et al. 2008). As a result, wounds and injuries heal more slowly in these animals, and penetration of allergens and other irritating substances is facilitated. Topical application of Spirulina has been found to accelerate wound healing and may be used for the treatment of various skin wounds, potentially providing a molecular basis for future promising scar-reducing agents (Elbialy et al. 2021).
• Elbialy ZI, Assar DH, Abdelnaby A, Asa SA, Abdelhiee EY, Ibrahim SS, Abdel-Daim MM, Almeer R, Atiba A. Healing potential of Spirulina platensis for skin wounds by modulating bFGF, VEGF, TGF-ß1 and α-SMA genes expression targeting angiogenesis and scar tissue formation in the rat model. Biomed Pharmacother. 2021 May;137:111349.

• Brito AF, Silva AS, de Oliveira CVC, de Souza AA, Ferreira PB, de Souza ILL, da Cunha Araujo LC, da Silva Félix G, de Souza Sampaio R, Tavares RL, de Andrade Pereira R, Neto MM, da Silva BA. Spirulina platensis prevents oxidative stress and inflammation promoted by strength training: dose-response relation study. Sci Rep. 2020 Apr 14;10(1):6382.
• “In humans, specifically, microalgae have proved effective in improving athlete sports performance thanks to their antioxidant activity [62]. A recent study carried out in rats also reported the effect of Spirulina in counteracting the fatigue of physical exercise [63].”  – Stefanutti D, Tonin G, Morelli G, Zampieri RM, La Rocca N, Ricci R. Oral Palatability and Owners’ Perception of the Effect of Increasing Amounts of Spirulina (Arthrospira platensis) in the Diet of a Cohort of Healthy Dogs and Cats. Animals. 2023;

• Seo Y-J, Kim K-J, Jia Choi J et al (2018). Spirulina maxima Extract Reduces Obesity through Suppression of Adipogenesis and Activation of Browning in 3T3-L1 Cells and High-Fat Diet-Induced Obese Mice. Nutrients 10(6):712.
• Diniz AFA, de Oliveira Claudino BF, Duvirgens MV, da Silva Souza PP, Ferreira PB, Júnior FFL, Alves AF, da Silva BA. Spirulina platensis Consumption Prevents Obesity and Improves the Deleterious Effects on Intestinal Reactivity in Rats Fed a Hypercaloric Diet. Oxid Med Cell Longev. 2021 Jul 27;2021:3260789.

“Spirulina has been amply reported in the literature to offer a valid support to the health of human skin and can thus be applied in the field of cosmetics [58]. In particular, A. Platensis has been shown to provide considerable benefits for the fibers composing the hair, making them brighter and easier to comb [59]. The benefits that Spirulina brings to the health of skin appendages probably derive from its rich nutritional profile because it has been shown that foods rich in antioxidants and omega-6 fatty acids can promote the protection of hair from oxidative stress derived from exposure to UV rays and environmental pollutants, improving shine and counteracting fall [60,61]. Furthermore, the excellent amino acid profile of the protein contained in A. Platensis may favor the composition of keratin of which human and animal hair are made. Other parameters evaluated in this study were scratching and lacrimation. Any variations in their manifestation are among the easiest signs for owners to notice; no significant variation between times was found in relation to these parameters.”  – Stefanutti D, Tonin G, Morelli G, Zampieri RM, La Rocca N, Ricci R. Oral Palatability and Owners’ Perception of the Effect of Increasing Amounts of Spirulina (Arthrospira platensis) in the Diet of a Cohort of Healthy Dogs and Cats. Animals. 2023; 13(8):1275. 

Due to its proven beneficial effects in treating periodontal diseases and reducing the accumulation of dental plaque, it can also be used preventively. “ – Katarzyna KAZIMIERSKA1 , Jagoda KĘPIŃSKA-PACELIK2 , Wioletta BIEL3, Arthrospira – Nutritional Value, Health-Promoting Properties And Possible Use As An Additive In Dog Nutrition. A Review, 2023

Due to its proven beneficial effects in treating periodontal diseases and reducing the accumulation of dental plaque, it can also be used preventively. “ – Katarzyna KAZIMIERSKA1 , Jagoda KĘPIŃSKA-PACELIK2 , Wioletta BIEL3, Arthrospira – Nutritional Value, Health-Promoting Properties And Possible Use As An Additive In Dog Nutrition. A Review, 2023

“Phycocyanin may be considered a safe drug to reduce or inhibit tumor cell growth.” – Braune S, Krüger-Genge A, Kammerer S, Jung F, Küpper J-H. Phycocyanin from Arthrospira platensis as Potential Anti-Cancer Drug: Review of In Vitro and In Vivo Studies. Life. 2021; 11(2):91.

• Teas J, Irhimeh M, Dietary algae and HIV/AIDS: Proof of concept clinical data, 2012
• A recent study on 60 dogs showed that after the first 2 weeks of this study using the starting amount of Spirulina, ~97% (n = 58/60) of owners said that administering Spirulina to their dog did not cause any problems, while 2 owners (3.3%) discontinued the supplementation because in 1 case the dog experienced diarrhea and 1 vomiting that continued even after supplementation was discontinued – so was probably unrelated… no change was detected in fecal score among periods (p = 0.669)  – Stefanutti D, Tonin G, Morelli G, Zampieri RM, La Rocca N, Ricci R. Oral Palatability and Owners’ Perception of the Effect of Increasing Amounts of Spirulina (Arthrospira platensis) in the Diet of a Cohort of Healthy Dogs and Cats. Animals. 2023; 13(8):1275. 
• The type of spirulina we use, A. platensis, is safe as it does not produce any cyanotoxin:  “Moreover, while A. platensis does not produce any cyanotoxin, other species of cyanobacteria that proliferate in the same environmental conditions may synthesize hepatoxic and neurotoxic agents” – Cheung, M.Y., Liang, S. & Lee, J. Toxin-producing cyanobacteria in freshwater: A review of the problems, impact on drinking water safety, and efforts for protecting public health. J Microbiol. 51, 1–10 (2013). https://doi.org/10.1007/s12275-013-2549-3